BOPI 03 BR / 2025 REPERTOIRE NUMERIQUE 14 Fig. 2 ________________________________________ (11) 21831 Consulter le mémoire (51) A61K 31/7072 (2018.01); A61P 29/00 (2018.01); A61P 31/18 (2018.01) (21) 1202300375 - PCT/US2022/020362 (22) 15/03/2022 (30) US n° 63/161,050 du 15/03/2021 (54) LINE-1 inhibitors to treat CNS and systemic diseases. (72) WEBER, Eckard (US) et CORDINGLEY, Michael G. (CA) (73) TRANSPOSON THERAPEUTICS, INC., 4660 La Jolla Village Drive, Suites 100 & 200, SAN DIEGO, California 92122 (US) (74) Cabinet Spoor & Fisher Inc. Ngwafor & Partners, The House of Gideon, Golf/Bastos Quater, Opposite The American Embassy, Entrance-Saint John Paul II Boulevard, P.O. Box 8211, YAOUNDE (CM). (57) The present disclosure provides methods of treating or preventing a CNS or systemic disease in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a LINE-1 inhibitor, or a pharmaceutical composition thereof. ________________________________________ (11) 21832 Consulter le mémoire (51) B07B 1/00 (2018.01); C01B 33/26 (2018.01); C01D 15/00 (2018.01); C01D 15/02 (2018.01); C22B 1/00 (2018.01) ; C22B 26/12 (2018.01) (21) 1202300391 - PCT/CA2022/050253 (22) 23/02/2022 (30) US n° 63/167, 851 du 30/03/2021 (54) Lithium recovery from spodumene. (72) FILLION, Mathieu (CA); GIROUX, Jean (CA) et HUBERT, Stéphane (CA) (73) RIO TINTO IRON AND TITANIUM CANADA INC., 1625 route Marie-Victorin, SOREL-TRACY, Québec J3R 1M6 (CA) (74) Cabinet Spoor & Fisher Inc. Ngwafor & Partners, The House of Gideon, Golf/Bastos Quater, Opposite The American Embassy, Entrance-Saint John Paul II Boulevard, P.O. Box 8211, YAOUNDE (CM). (57) The present disclosure relates to a method of producing a lithium concentrate from a calcined
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