BOPI 04 BR / 2025 REPERTOIRE NUMERIQUE 15 (54) Indazole based compounds and associated methods of use. (72) DONG, Hanqing (US); WANG, Jing (US); ARAUJO, Erika (US); BERLIN, Michael (US); SPARKS, Steven, M. (US) et ZHANG, Wei (US) (73) ARVINAS OPERATIONS, INC., 5 Science Park, NEW HAVEN, CT 06511 (US) (74) Cabinet Spoor & Fisher Inc. Ngwafor & Partners, The House of Gideon, Golf/Bastos Quater, Opposite The American Embassy, Entrance-Saint John Paul II Boulevard, P.O. Box 8211, YAOUNDE (CM). (57) Bifunctional compounds, of formula PTM-L-CLM, where the CLM is of formulae a1-a4, the PTM f formula PTM-IA and L is a ligand. These compounds act on several diseases via agonism on LRRK2 and cereblon E3 ubiquitin ligase. Fig. 1A; Fig. 1B & Bifunctional compounds ________________________________________ (11) 21864 Consulter le mémoire
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