BOPI 04 BR / 2025 REPERTOIRE NUMERIQUE 16 (51) C07D 231/14 (2018.01); C07D 401/04 (2018.01); C07D 401/12 (2018.01) (21) 1202300425 - PCT/US2022/024805 (22) 14/04/2022 (30) US n° 63/174, 860 du 14/04/2021 (54) Bicyclic Heteroaromatic Inhibitors Of KLK5. (72) BABU, Yarlagadda, S. (US); KOTIAN, Pravin, L. (US); ZHANG, Weihe (US); LU, Peng-Cheng (US); DANG, Zhao (US) et RAMAN, Krishnan (US) (73) BIOCRYST PHARMACEUTICALS, INC., 4505 Emperor Blvd., Suite 200, DURHAM, NC 27703 (US) (74) Cabinet Spoor & Fisher Inc. Ngwafor & Partners, The House of Gideon, Golf/Bastos Quater, Opposite The American Embassy, Entrance-Saint John Paul II Boulevard, P.O. Box 8211, YAOUNDE (CM). (57) Disclosed are compounds of formulae (I) - (IV), and pharmaceutically acceptable salts thereof, which are inhibitors of kallikrein-related peptidase 5 (KLK5). Also provided are pharmaceutical compositions comprising such a compound, and methods of using the compounds and compositions in the treatment or prevention of a disease or condition characterized by aberrant KLK5 activity activity, such as Netherton Syndrome. Compounds of formulae (I) - (IV) ________________________________________ (11) 21865 Consulter le mémoire (51) H01M 10/44 (2023.01); H02J 7/00 (2023.01) (21) 1202400134 - PCT/JP2022/038579 (22) 17/10/2022 (30) JP n° PCT/JP2021/039644 du 27/10/2021 (54) Power-storage-type charging apparatus, power-storage-type charging system, and high-current chargeable driving lithium-ion battery.
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